Recent Publications
Updated 22/10/2020
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Et3SiH + KOtBu Provide Multiple Reactive Intermediates that Compete in the Reactions and Rearrangements of Benzylnitriles and Indolenines
Smith, A. J.; Arokianathar, J.; Clark, K.; Leach, S. G.; Poole, D. L.; Murphy, J. A., Chem. Sci. 2020 |
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Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core
Lippa, R. A.; Barrett, J.; Pal, S.; Rowedder, J. E.; Murphy, J. A.; Barrett, T. N., Eur. J. Med. Chem. 2020 |
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Visible Light-Mediated Smiles Rearrangements and Annulations of Non-Activated Aromatics
Lawson, C. A.; Dominey, A. P.; Williams, G. D.; Murphy, J. A., Chem. Commun. 2020 |
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Computational Study on the Boundary Between the Concerted and Stepwise Mechanism of Bimolecular SNAr Reactions
Rohrbach, S.; Murphy, J. A.; Tuttle, T., J. Am. Chem. Soc. 2020 |
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Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using Horner-Wadsworth-Emmons-based approach
Lippa, R. A.; Murphy, J. A., Barrett, T. N., Beilstein J. Org. Chem. 2020, 16, 1617-1626 |
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Benzylic C-H functionalisation by [Et3SiH+KOtBu] leads to radical rearrangements in o-tolylaryl ethers, amines and sulfides
Arokianathar, J.; Kolodziejczak, K.; Bugden, F.; Clark, K.; Tuttle, T.; Murphy, J. A., Adv. Synth. Catal., 2020 |
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New reductive rearrangement of N-arylindoles triggered by the Grubbs-Stoltz reagent Et3SiH/KOtBu
Smith, A. J.; Dimitrova, D.; Arokianathar, J. N.; Kolodziejczak, K.; Young, A.; Allison, M.; Poole, D. L.; Leach, S. G.; Parkinson, J. A.; Tuttle, T.; Murphy, J. A., Chem. Sci., 2020 |
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Hi-JAK-ing The Ubiquitin System: The Design and Physicochemical Optimi-sation of JAK PROTACs
Shah, R. R.; Redmond, J. M.; Mihut, A.; Menon, M.; Evans, J. P.; Murphy, J. A.; Bartholomew, M. A.; Coe, D. M., Bioorg. Med. Chem., 2020 |
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Hydrogen Atom Transfer‐Mediated Domino Cyclisation Reaction to Access (Spiro)Quinazolinones
Turner, O.: Hirst, D,: Murphy, J. A., Chem. Eur. J., 2020 |
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N-Silylation of Amines Mediated by Et3SiH/KOtBu
Palumbo, F.; Rohrbach, S.; Tuttle, T.; Murphy, J. A., Helv. Chim. Acta., 2019 |
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The role of organic electron donors in the initiation of BHAS base-induced coupling reactions between haloarenes and arenes
Smith, A. J.; Poole, D.; Murphy, J. A., Sci. China Chem., 2019 |
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The Right Light - De Novo Design of a Robust Modular Photochemical Reactor for Optimum Batch and Flow Chemistry
Bonfield, H. E.; Mercer, K.; Diaz-Rodriguez, D.; Cook, G. C.; McKay, B.; Slade, P.; Taylor, G. M.; Ooi, W. X.; Williams, J. D.; Roberts, J. P. M.; Murphy, J. A.; Schmermund, L.; Kroutil, W.; Mielke, T.; Cartwright, J.; Grogan, G.; Edwards, L. J., ChemPhotoChem., 2019 |
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Ground State Cross-Coupling of Haloarenes with Arenes Initiated by Organic Electron Donors, Formed in situ: An Overview
Nocera, G.; Murphy, J. A., Synthesis, 2019 |
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Neutral Organic Super Electron Donors Made Catalytic
Rohrbach, S.; Shah, R. S.; Tuttle, T.; Murphy, J. A., Angew. Chem. Int. Ed., 2019 (Highlighted as a very important publication (VIP)) |
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Concerted Nucleophilic Aromatic Substitution Reactions
Rohrbach, S.; Smith, A. J.; Pang, J. H.; Poole, D. L.; Tuttle, T.; Chiba, S.; Murphy, J. A., Angew. Chem. Int. Ed., 2019 |
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Hydrogen Atom Transfer-Mediated Cyclisations of Nitriles
Turner, O. J.; Murphy, J. A.; Hirst, D. J.; Talbot, E. P. A., Chem. Eur. J., 2018 |
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Dual Roles for Potassium Hydride in Haloarene Reduction: CSNAr and SET Reduction via Organic Electron Donors Formed in Benzene
Barham, J. P.; Dalton, S. E.; Allison, M.; Nocera, G.; Young, A.; John, M. P.; McGuire, T. M.; Campos, S.; Tuttle, T.; Murphy, J. A., J. Am. Chem. Soc., 2018 |
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Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry
Bogdos, M. K.; Pinard, E.; Murphy, J. A., Beilstein J. Org. Chem., 2018 |
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Electron Transfer reactions: KOtBu (but not NaOtBu) Photo-reduces Benzophenone, under Activation by Visible Light
Nocera, G.; Young, A.; Palumbo, F.; Emery, K. J.; Coulthard, G.; McGuire, T. M.; Tuttle, T.; Murphy, J. A., J. Am. Chem. Soc., 2018 |
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KOtBu as a single electron donor? Revisiting the halogenation of alkanes with CBr4 and CCl4
Emery, K. J.; Young, A.; Arokianathar, J. N.; Tuttle, T.; Murphy, J. A., Molecules, 2018 |
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Reduction of nitroarenes, azoarenes and hydrazine derivatives by an organic electron donor
Cumine, F.; Palumbo, F.; Murphy, J. A., Tetrahedron, 2018 |
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Selectively targeting the kinome-conserved lysine of PI3Kdelta as a general approach to covalent kinase inhibition
Dalton, S. E.; Dittus, L.; Thomas, D. A.; Convery, M. A.; Nunes, J.; Bush, J. T.; Evans, J. P.; Werner, T.; Bantscheff, M.; Murphy, J. A.; Campos, S., J. Am. Chem. Soc., 2018 |
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A computational study of anionic alkoxide-allene and amide-allene cyclizations
Cumine, F.; Young, A.; Reissig, H.-U.; Tuttle, T.; Murphy, J. A., Eur. J. Org. Chem., 2017 |
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Evidence of single electron transfer from the enolate anion of an N,N'-dialkyldiketopiperazine additive in BHAS coupling reactions
Emery, K. J.; Tuttle, T.; Murphy, J. A., Org. Biomol. Chem., 2017 |
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Electron Transfer and Hydride Transfer Pathways in the Stoltz-Grubbs Reducing System (KOtBu-Et3SiH)
Smith, A. J.; Young, A.; Rohrbach, S.; O'Connor, E. F.; Allison, M.; Wang, H.-S.; Poole, D. L.; Tuttle, T.; Murphy, J. A., Angew. Chem. Int. Ed., 2017 |
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A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene-arene coupling
Cumine, F.; Zhou, S.; Tuttle, T.; Murphy, J. A., Org. Biomol. Chem., 2017 |
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Effect of solvent on radical cyclisation pathways: SRN1 vs. aryl-aryl bond forming mechanisms
Emery, K. J.; Murphy, J. A.; Tuttle, T., Org. Biomol. Chem., 2017 |
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Contra-thermodynamic Hydrogen Atom Abstraction in the Selective C–H Functionalization of Trialkylamine N-CH3 Groups
Barham, J. P.; John, M. P.; Murphy, J. A., J. Am. Chem. Soc., 2016 |
C-C Bond-Forming Reactions of Ground-State Aryl Halides Under Reductive Activation
Emery, K. J.; Tuttle, T.; Kennedy, A. R.; Murphy, J. A., Tetrahedron, 2016
Emery, K. J.; Tuttle, T.; Kennedy, A. R.; Murphy, J. A., Tetrahedron, 2016
KOtBu: a Privileged Reagent for Electron Transfer Reactions?
Barham, J. P.; Coulthard, G.; Emery, K. J.; Doni, E.; Cumine, F.; Nocera, G.; John, M. P.; Berlouis, L. E. A.; McGuire, T. M.; Tuttle, T.; Murphy, J. A., J. Am. Chem. Soc., 2016
Barham, J. P.; Coulthard, G.; Emery, K. J.; Doni, E.; Cumine, F.; Nocera, G.; John, M. P.; Berlouis, L. E. A.; McGuire, T. M.; Tuttle, T.; Murphy, J. A., J. Am. Chem. Soc., 2016
Proton Transfer Reactions of a Bridged Bis-Propyl Bis-Imidazolium Salt
Massey, R. S.; Quinn, P.; Zhou, S.; Murphy, J. A.; O'Donoghue, A. C., J. Phys. Org. Chem., 2016
Massey, R. S.; Quinn, P.; Zhou, S.; Murphy, J. A.; O'Donoghue, A. C., J. Phys. Org. Chem., 2016
Double Deprotonation of Pyridinols Generates Potent Organic Electron-Donor Initiators for Haloarene-Arene Coupling
Barham, J. P.; Coulthard, G.; Kane, R. G.; Delgado, N.; John, M. P.; Murphy, J. A., Angew. Chem. Int. Ed., 2016
Barham, J. P.; Coulthard, G.; Kane, R. G.; Delgado, N.; John, M. P.; Murphy, J. A., Angew. Chem. Int. Ed., 2016
Predicting the Reducing Power of Organic Super Electron Donors
Anderson, G. M.; Cameron, I.; Murphy, J. A.; Tuttle, T., RSC Adv., 2016
Anderson, G. M.; Cameron, I.; Murphy, J. A.; Tuttle, T., RSC Adv., 2016
Pushing the Limits of Neutral Organic Electron Donors: A Tetra(iminophosphorano)-Substituted Bispyridinylidene
Hanson, S. S.; Doni, E.; Traboulsee, K. T.; Coulthard, G.; Murphy, J. A.; Dyker, C. A., Angew. Chem. Int. Ed., 2015
Hanson, S. S.; Doni, E.; Traboulsee, K. T.; Coulthard, G.; Murphy, J. A.; Dyker, C. A., Angew. Chem. Int. Ed., 2015
Electron Transfer-Induced Coupling of Haloarenes to Styrenes and 1,1-Diphenylethenes Triggered by Diketopiperazines and Potassium tert-Butoxide
Doni, E.; Zhou, S.; Murphy, J. A., Molecules, 2015
Doni, E.; Zhou, S.; Murphy, J. A., Molecules, 2015
"The Third Hydrogenase" Chap. 5 in "Bioinspired Catalysis: Metal-Sulfur Complexes" W. Weigand, P. Schollhammer (Editors) ISBN: 978-3-527-33308-0, 440 pages, October 2014, Wiley.
Scullion, C.; Murphy, J. A.
Scullion, C.; Murphy, J. A.
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